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Buffalo Bills vs Detroit Lions predictions, Sep 17, 2026

Yuriy Borshchenko

NFL, on Thursday,

Score, Highlights

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As the Buffalo Bills prepare to host the Detroit Lions on September 17, 2026, both teams enter the matchup with positive momentum, showcasing their competitive edge in recent outings. The Bills have been particularly impressive, securing victories in all three of their last matches. Their offense has displayed a potent blend of precision and explosiveness, allowing them to maintain control of games and dictate the tempo on the field.

Conversely, the Lions arrive with two wins in their last three contests, signaling a resilience and capacity to perform under pressure. Known for their dynamic offensive strategy, the Lions have effectively utilized a range of plays to exploit defensive weaknesses, particularly in the passing game.

Bookmakers currently favor the Bills with odds of 1.59 for a home win compared to the Lions’ 2.39. The predicted final score suggests a close contest, projecting a score of 28:25. As both teams are fighting for form and positioning, the matchup promises to be a competitive clash, with neither side able to claim definitive superiority. Bettors should assess current tactical approaches and recent performances while considering the unpredictability inherent in any NFL matchup.

This preview is generated with the Welcome.Bet AI Insights Engine, combining form data, betting odds, and semantic SEO optimization to deliver relevant match analysis for fans and bettors alike from 2026-09-12T03:52:02+00:00.

Buffalo
60.3%		 Detroit
39.7%

Prediction (the most likely score): 28:25

Outrights of NFL Buffalo Bills: 7.47% Detroit Lions: 4.32%

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Betting Odds

1 X 2
1.55 2.45
1.63 2.35
1.54 2.35
1.55 2.41

Latest Results

27.08.26 Buffalo Bills – Pittsburgh Steelers – 28:27
22.08.26 Cleveland Browns – Buffalo Bills – 7:31
15.08.26 Buffalo Bills – Carolina Panthers – 29:14
17.01.26 Denver Broncos – Buffalo Bills – 33:30 OT
11.01.26 Jacksonville Jaguars – Buffalo Bills – 24:27		 29.08.26 Indianapolis Colts – Detroit Lions – 16:25
22.08.26 Detroit Lions – Washington Commanders – 17:13
13.08.26 Cincinnati Bengals – Detroit Lions – 16:14
04.01.26 Chicago Bears – Detroit Lions – 16:19
25.12.25 Minnesota Vikings – Detroit Lions – 23:10

Facts

  • In the last 5 head-to-head matches, Buffalo won 5.
  • Buffalo will hold a modest advantage in this match.
  • We predict that Buffalo will win today’s game, with odds of 1.58.
  • In the last 12 head-to-head matches, Buffalo won 7 matches, drew 0 matches, lost 5 matches, and goals 229:290. (average 19.1:24.2).
  • Including home matches between the teams, Buffalo won 2 matches, drew 0 matches, lost 2 matches, and goals 54:88. (average 13.5:22).

    Latest Head To Head

    15.12.24 Detroit Lions – Buffalo Bills – 42:48
    24.11.22 Detroit Lions – Buffalo Bills – 25:28
    13.08.21 Detroit Lions – Buffalo Bills – 15:16
    23.08.19 Detroit Lions – Buffalo Bills – 20:24
    16.12.18 Buffalo Bills – Detroit Lions – 14:13

    Standings

    Main

    American Football

    Pl W D L PCT
    1 Pittsburgh Steelers 0 0 0 0 0:0 0.000
    2 Indianapolis Colts 0 0 0 0 0:0 0.000
    3 Cleveland Browns 0 0 0 0 0:0 0.000
    4 Las Vegas Raiders 0 0 0 0 0:0 0.000
    5 Denver Broncos 0 0 0 0 0:0 0.000
    6 Miami Dolphins 0 0 0 0 0:0 0.000
    7 Baltimore Ravens 0 0 0 0 0:0 0.000
    8 Kansas City Chiefs 0 0 0 0 0:0 0.000
    9 New York Jets 0 0 0 0 0:0 0.000
    10 Cincinnati Bengals 0 0 0 0 0:0 0.000
    11 Buffalo Bills 0 0 0 0 0:0 0.000
    12 Houston Texans 0 0 0 0 0:0 0.000
    13 Tennessee Titans 0 0 0 0 0:0 0.000
    14 Jacksonville Jaguars 0 0 0 0 0:0 0.000
    15 Los Angeles Chargers 0 0 0 0 0:0 0.000
    16 New England Patriots 1 0 0 1 10:13 0.000

    National Football

    Pl W D L PCT
    1 San Francisco 49ers 1 1 0 0 27:7 1.000
    2 Seattle Seahawks 1 1 0 0 13:10 1.000
    3 Green Bay Packers 0 0 0 0 0:0 0.000
    4 Chicago Bears 0 0 0 0 0:0 0.000
    5 New York Giants 0 0 0 0 0:0 0.000
    6 Dallas Cowboys 0 0 0 0 0:0 0.000
    7 Washington Commanders 0 0 0 0 0:0 0.000
    8 Detroit Lions 0 0 0 0 0:0 0.000
    9 Philadelphia Eagles 0 0 0 0 0:0 0.000
    10 Arizona Cardinals 0 0 0 0 0:0 0.000
    11 Minnesota Vikings 0 0 0 0 0:0 0.000
    12 Tampa Bay Buccaneers 0 0 0 0 0:0 0.000
    13 Atlanta Falcons 0 0 0 0 0:0 0.000
    14 New Orleans Saints 0 0 0 0 0:0 0.000
    15 Carolina Panthers 0 0 0 0 0:0 0.000
    16 Los Angeles Rams 1 0 0 1 7:27 0.000

    NFL Outrights

    1. Los Angeles Rams: 7 (11.74%)

    2. Buffalo Bills: 11 (7.47%)

    3. Seattle Seahawks: 12 (6.85%)

    4. Baltimore Ravens: 12 (6.85%)

    5. San Francisco 49ers: 16 (5.14%)

    6. Kansas City Chiefs: 17 (4.83%)

    7. Los Angeles Chargers: 17 (4.83%)

    8. Detroit Lions: 19 (4.32%)

    9. Houston Texans: 19 (4.32%)

    10. Cincinnati Bengals: 19 (4.32%)

    11. Philadelphia Eagles: 19 (4.32%)

    12. New England Patriots: 21 (3.91%)

    13. Denver Broncos: 21 (3.91%)

    14. Green Bay Packers: 21 (3.91%)

    15. Dallas Cowboys: 23 (3.57%)

    16. Chicago Bears: 26 (3.16%)

    17. Jacksonville Jaguars: 29 (2.83%)

    18. Minnesota Vikings: 46 (1.79%)

    19. Tampa Bay Buccaneers: 51 (1.61%)

    20. Indianapolis Colts: 56 (1.47%)

    21. Pittsburgh Steelers: 56 (1.47%)

    22. Washington Commanders: 61 (1.35%)

    23. New York Giants: 66 (1.24%)

    24. Carolina Panthers: 91 (0.9%)

    25. New Orleans Saints: 91 (0.9%)

    26. Atlanta Falcons: 101 (0.81%)

    27. Tennessee Titans: 151 (0.54%)

    28. Las Vegas Raiders: 151 (0.54%)

    29. Cleveland Browns: 201 (0.41%)

    30. New York Jets: 251 (0.33%)

    31. Miami Dolphins: 501 (0.16%)

    32. Arizona Cardinals: 501 (0.16%)

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