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St. Louis Cardinals vs Pittsburgh Pirates predictions, May 21, 2026

Yuriy Borshchenko

MLB, Busch Stadium (St. Louis, MO) on Thursday,

Score, Highlights

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On May 21, 2026, the St. Louis Cardinals will host the Pittsburgh Pirates at their home venue, looking to maintain their strong recent form. The Cardinals have won 4 of their last 5 matches, showcasing a solid offensive unit and effective pitching, which has contributed to their increasing confidence on the field.

In contrast, the Pittsburgh Pirates have struggled lately, managing to secure only 1 win in their previous 5 outings. This poor run hints at potential weaknesses in their batting lineup and defensive capabilities, which could be exploited by a high-flying Cardinals team.

Current bookmaker odds favor the away team slightly, with the Pirates at 1.78 compared to the Cardinals at 2.09. However, our model indicates a close contest, with probabilities calculated at 47.8% for a home win and 52.2% for an away victory. The predicted final score suggests a competitive matchup, forecasting a 3:5 outcome in favor of the Pirates.

Overall, while recent trends favor the Cardinals, the game’s nature emphasizes the unpredictability inherent in baseball, making it crucial for bettors to weigh all factors before placing their wagers.

This preview is generated with the Welcome.Bet AI Insights Engine, combining form data, betting odds, and semantic SEO optimization to deliver relevant match analysis for fans and bettors alike from 2026-05-20T21:52:02+00:00.

St. Louis
46%		 Pittsburgh
54%

Prediction (the most likely score): 3:5

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Betting Odds

1 X 2
2.17 1.79
2.05 1.75

Latest Results

19.05.26 St. Louis Cardinals – Pittsburgh Pirates – 9:6
17.05.26 St. Louis Cardinals – Kansas City Royals – 0:2
16.05.26 St. Louis Cardinals – Kansas City Royals – 4:2
15.05.26 St. Louis Cardinals – Kansas City Royals – 5:4
14.05.26 Athletics Baseball – St. Louis Cardinals – 4:5		 19.05.26 St. Louis Cardinals – Pittsburgh Pirates – 9:6
17.05.26 Pittsburgh Pirates – Philadelphia Phillies – 0:6
16.05.26 Pittsburgh Pirates – Philadelphia Phillies – 9:11
15.05.26 Pittsburgh Pirates – Philadelphia Phillies – 9:11
14.05.26 Pittsburgh Pirates – Colorado Rockies – 7:2

Facts

  • One team leads the standings, the other sits mid-table (ranked 5 and 11).
  • In the last 5 head-to-head matches, St. Louis won 5.
  • St. Louis is undoubtedly in great shape (last 5 games: 4 wins).
  • Pittsburgh is currently in poor form (in the last 5 games, wins – 1).
  • Recently, the opponents have had a series of home games.
  • In this match, both teams have almost equal chances to win.
  • In the last 20 head-to-head matches, St. Louis won 12 matches, drew 0 matches, lost 8 matches, and goals 81:79. (average 4.1:4).
  • Including home matches between the teams, St. Louis won 6 matches, drew 0 matches, lost 3 matches, and goals 38:33. (average 4.2:3.7).

    Latest Head To Head

    19.05.26 St. Louis Cardinals – Pittsburgh Pirates – 9:6
    30.04.26 Pittsburgh Pirates – St. Louis Cardinals – 5:10
    29.04.26 Pittsburgh Pirates – St. Louis Cardinals – 4:5
    28.04.26 Pittsburgh Pirates – St. Louis Cardinals – 7:11
    27.04.26 Pittsburgh Pirates – St. Louis Cardinals – 2:4

    Standings

    Main

    American League

    Pl W L PCT
    1 Tampa Bay Rays 48 33 15 232:192 0.688
    2 New York Yankees 49 30 19 249:179 0.612
    3 Cleveland Guardians 51 29 22 225:204 0.569
    4 Chicago White Sox 49 25 24 218:230 0.510
    5 Athletics 48 24 24 215:221 0.500
    6 Texas Rangers 49 24 25 192:179 0.490
    7 Seattle Mariners 51 24 27 210:199 0.471
    8 Minnesota Twins 50 23 27 230:231 0.460
    9 Toronto Blue Jays 48 21 27 198:211 0.438
    10 Boston Red Sox 48 21 27 177:189 0.438
    11 Baltimore Orioles 50 21 29 215:274 0.420
    12 Kansas City Royals 49 20 29 191:220 0.408
    13 Detroit Tigers 50 20 30 195:216 0.400
    14 Houston Astros 51 20 31 218:274 0.392
    15 Los Angeles Angels 49 17 32 194:261 0.347

    National League

    Pl W L PCT
    1 Atlanta Braves 50 34 16 267:169 0.680
    2 Los Angeles Dodgers 49 30 19 253:159 0.612
    3 Milwaukee Brewers 46 28 18 232:162 0.609
    4 San Diego Padres 48 29 19 200:193 0.604
    5 St.Louis Cardinals 47 28 19 217:211 0.596
    6 Chicago Cubs 49 29 20 246:213 0.592
    7 Arizona Diamondbacks 48 25 23 221:223 0.521
    8 Cincinnati Reds 50 26 24 221:249 0.520
    9 Washington Nationals 50 25 25 279:294 0.500
    10 Philadelphia Phillies 50 25 25 209:233 0.500
    11 Pittsburgh Pirates 48 24 24 235:220 0.500
    12 Miami Marlins 50 22 28 218:231 0.440
    13 New York Mets 49 21 28 202:216 0.429
    14 San Francisco Giants 50 20 30 173:225 0.400
    15 Colorado Rockies 50 19 31 210:264 0.380

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