Cleveland Guardians vs Houston Astros predictions, Apr 22, 2026

Apr 21, 2026 0 Comment By Yuriy Borshchenko

MLB, on Wednesday,

Guardians

Astros

Score, Highlights

Short Preview

As the Cleveland Guardians prepare to host the Houston Astros on April 22, 2026, both teams come into the matchup with contrasting recent performances. The Guardians have managed to secure victories in 3 of their last 5 games, showcasing solid pitching and a gradually improving offense. Their ability to perform effectively at home will be a critical factor as they face off against the Astros.

On the other hand, the Astros are struggling, having won only 1 of their last 5 matches. Despite their historical strength as a playoff contender, they have faced challenges in maintaining consistent form, which has impacted their standings. The Astros will need to find a way to rejuvenate their lineup and regain the competitive edge that has defined their recent seasons.

Bookmakers currently favor the Guardians slightly, assigning them odds of 1.79 for a home victory compared to 2.06 for an Astros win. Our model calculates a 52.4% probability of a home win, indicating a narrow edge for Cleveland. In this matchup, the Guardians will look to capitalize on their recent momentum while the Astros aim to turn their fortunes around. As always in baseball, while trends can indicate possible outcomes, the unpredictability of the game remains ever-present.

This preview is generated with the Welcome.Bet AI Insights Engine, combining form data, betting odds, and semantic SEO optimization to deliver relevant match analysis for fans and bettors alike from 2026-04-21T15:52:03+00:00.

Cleveland
53.5%		 Houston
46.5%

Outrights of MLB Houston Astros: 1.57% Cleveland Guardians: 1.4%

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Betting Odds

1 X 2
betsson 1.76 2.07
MarathonBet 1.86 2.07
WilliamHill 1.75 2.05

Latest Results

20.04.26 Cleveland Guardians – Houston Astros – 2:9
19.04.26 Cleveland Guardians – Baltimore Orioles – 8:4
18.04.26 Cleveland Guardians – Baltimore Orioles – 4:2
17.04.26 Cleveland Guardians – Baltimore Orioles – 4:6
16.04.26 Cleveland Guardians – Baltimore Orioles – 4:2		 20.04.26 Cleveland Guardians – Houston Astros – 2:9
19.04.26 Houston Astros – St. Louis Cardinals – 5:7
18.04.26 Houston Astros – St. Louis Cardinals – 5:7
17.04.26 Houston Astros – St. Louis Cardinals – 4:9
16.04.26 Houston Astros – Colorado Rockies – 2:3

Facts

  • A leader and an outsider will face off in this match (ranked 3 and 13).
  • In the last 5 head-to-head matches, Cleveland won 4.
  • In recent matches, Cleveland has shown inconsistent form (last 5 games: 3 wins).
  • Houston is currently in poor form (in the last 5 games, wins – 1).
  • Recently, the opponents have had a series of home games.
  • In this match, both teams have almost equal chances to win.
  • In the last 20 head-to-head matches, Cleveland won 9 matches, drew 0 matches, lost 11 matches, and goals 76:89. (average 3.8:4.5).
  • Including home matches between the teams, Cleveland won 5 matches, drew 0 matches, lost 6 matches, and goals 36:44. (average 3.3:4).

    Latest Head To Head

    20.04.26 Cleveland Guardians – Houston Astros – 2:9
    09.07.25 Houston Astros – Cleveland Guardians – 2:4
    08.07.25 Houston Astros – Cleveland Guardians – 6:10
    07.07.25 Houston Astros – Cleveland Guardians – 5:7
    08.06.25 Cleveland Guardians – Houston Astros – 4:2

    Standings

    Main

    American League

    Pl W L PCT
    1 New York Yankees 22 13 9 110:82 0.591
    2 Tampa Bay Rays 22 12 10 104:115 0.545
    3 Cleveland Guardians 24 13 11 97:104 0.542
    4 Detroit Tigers 23 12 11 100:83 0.522
    5 Athletics 23 12 11 97:114 0.522
    6 Texas Rangers 22 11 11 92:82 0.500
    7 Minnesota Twins 22 11 11 112:100 0.500
    8 Baltimore Orioles 23 11 12 98:103 0.478
    9 Los Angeles Angels 24 11 13 117:109 0.458
    10 Seattle Mariners 24 10 14 94:90 0.417
    11 Toronto Blue Jays 22 9 13 88:111 0.409
    12 Boston Red Sox 22 9 13 89:102 0.409
    13 Houston Astros 24 9 15 130:142 0.375
    14 Chicago White Sox 22 8 14 82:113 0.364
    15 Kansas City Royals 23 7 16 76:110 0.304

    National League

    Pl W L PCT
    1 Los Angeles Dodgers 22 16 6 133:76 0.727
    2 Atlanta Braves 23 16 7 131:69 0.696
    3 San Diego Padres 22 15 7 96:79 0.682
    4 Cincinnati Reds 23 15 8 84:87 0.652
    5 Arizona Diamondbacks 22 13 9 99:102 0.591
    6 Chicago Cubs 22 13 9 117:83 0.591
    7 Pittsburgh Pirates 22 13 9 113:88 0.591
    8 St.Louis Cardinals 22 13 9 106:116 0.591
    9 Milwaukee Brewers 21 12 9 106:87 0.571
    10 Miami Marlins 23 11 12 105:104 0.478
    11 Washington Nationals 23 10 13 125:143 0.435
    12 San Francisco Giants 22 9 13 75:96 0.409
    13 Colorado Rockies 23 9 14 92:111 0.391
    14 Philadelphia Phillies 22 8 14 76:118 0.364
    15 New York Mets 22 7 15 72:97 0.318

    MLB Outrights

    1. Los Angeles Dodgers: 2.23 (28.91%)

    2. New York Yankees: 9 (7.16%)

    3. New York Mets: 11.08 (5.81%)

    4. Atlanta Braves: 11.36 (5.67%)

    5. Philadelphia Phillies: 11.88 (5.42%)

    6. Chicago Cubs: 13.8 (4.67%)

    7. Seattle Mariners: 14 (4.6%)

    8. Milwaukee Brewers: 16.76 (3.84%)

    9. Detroit Tigers: 19 (3.39%)

    10. Toronto Blue Jays: 20 (3.22%)

    11. San Diego Padres: 21.4 (3.01%)

    12. Pittsburgh Pirates: 22.2 (2.9%)

    13. Baltimore Orioles: 23 (2.8%)

    14. Boston Red Sox: 26 (2.48%)

    15. Texas Rangers: 26 (2.48%)

    16. Cincinnati Reds: 30.2 (2.13%)

    17. Houston Astros: 41 (1.57%)

    18. Arizona Diamondbacks: 41.4 (1.56%)

    19. Cleveland Guardians: 46 (1.4%)

    20. San Francisco Giants: 48.2 (1.34%)

    21. Kansas City Royals: 51 (1.26%)

    22. Tampa Bay Rays: 67 (0.96%)

    23. Miami Marlins: 100.2 (0.64%)

    24. Athletics: 101 (0.64%)

    25. St.Louis Cardinals: 115.2 (0.56%)

    26. Minnesota Twins: 126 (0.51%)

    27. Washington Nationals: 180.2 (0.36%)

    28. Los Angeles Angels: 201 (0.32%)

    29. Colorado Rockies: 280.2 (0.23%)

    30. Chicago White Sox: 401 (0.16%)

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